Article
Rational design and eco-friendly one-pot multicomponent synthesis of novel ethylidenehydrazineylthiazol-4(5H)-ones as potential apoptotic inducers targeting wild and mutant EGFR-TK in triple negative breast cancer.
Bioorganic chemistry - 1 Jan 2024
Abbass Eslam M, Al-Karmalawy Ahmed A, Sharaky Marwa, Khattab Muhammad, Alzahrani Abdullah Yahya Abdullah, Hassaballah Aya I
Abstract excerpt
A novel series of ethylidenehydrazineylthiazol-4(5H)-ones were synthesized using various eco-friendly one-pot multicomponent synthetic techniques. The anticancer activity of compounds (4a-m) was tested against 11 cancer cell lines. While the IC50 of all compounds was evaluated against the most sensitive cell lines (MDA-MB-468 and FaDu). Our SAR study pinpointed that compound 4a, having a phenyl substituent,...
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