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Article

Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFRWT and EGFRT790M inhibitors.

Journal of enzyme inhibition and medicinal chemistry - 1 Dec 2023

Al-Warhi Tarfah, Al-Karmalawy Ahmed A, Elmaaty Ayman Abo, Alshubramy Maha A, Abdel-Motaal Marwa, Majrashi Taghreed A, Asem Medhat, Nabil Ahmed, Eldehna Wagdy M, Sharaky Marwa

Abstract excerpt

Herein, a set of pyridine and pyrimidine derivatives were assessed for their impact on the cell cycle and apoptosis. Human breast cancer (MCF7), hepatocellular carcinoma (HEPG2), larynx cancer (HEP2), lung cancer (H460), colon cancers (HCT116 and Caco2), and hypopharyngeal cancer (FADU), and normal Vero cell lines were used. Compounds 8 and 14 displayed outstanding effects on the investigated cell lines and were...

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Identifiers

PMID: 36317648
DOI: 10.1080/14756366.2022.2135512
PMCID: PMC9635468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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