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Article

Discovery of new 1H-pyrazolo[3,4-d]pyrimidine derivatives as anticancer agents targeting EGFRWT and EGFRT790M.

Journal of enzyme inhibition and medicinal chemistry - 1 Dec 2022

Gaber Ahmed A, Sobhy Mohamed, Turky Abdallah, Abdulwahab Hanan Gaber, Al-Karmalawy Ahmed A, Elhendawy Mostafa A, Radwan Mohamed M, Elkaeed Eslam B, Ibrahim Ibrahim M, Elzahabi Heba S A, Eissa Ibrahim H

Abstract excerpt

New 1H-pyrazolo[3,4-d]pyrimidine derivatives were designed and synthesised to act as epidermal growth factor receptor inhibitors (EGFRIs). The synthesised derivatives were assessed for their in vitro anti-proliferative activities against A549 and HCT-116 cancer cells. Compounds 8, 10, 12a, and 12b showed potent anti-proliferative activities. Compound 12b was the most promising member with IC50 values of 8.21 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36000168
DOI: 10.1080/14756366.2022.2112575
PMCID: PMC9466626

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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