Article
Microwave-assisted synthesis, spectroscopic characterization, and biological evaluation of fused thieno[2,3-d]pyrimidines as potential anti-cancer agents targeting EGFRWT and EGFRT790M.
Molecular diversity - 1 Apr 2023
Aboelez Moustafa O, Kamel Moumen S, Belal Amany, El Badry Abdel-Aziz Ahmed, Abourehab Mohammed A S, Abdel-Ghany H, A El Hamd Mohamed, El-Remaily Mahmoud Abd El Aleem Ali
Abstract excerpt
Epidermal growth factor receptor (EGFR) is a transmembrane protein tyrosine kinase that is usually overexpressed in many types of cancers. In the present study, an effort was done in synthesis of new 3,4-diaminothieno[2,3-b] thiophene-2,5-dicarbonitrile derivatives 2-8, assisted by a microwave device. Different spectroscopic instruments were used for their analysis and confirmed their chemical structures. The...
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