Article
Antitumor activity and mechanisms of dual EGFR/DNA-targeting strategy for the treatment of lung cancer with EGFRL858R/T790M mutation.
Bioorganic chemistry - 1 Jun 2023
Dai Lumei, Qin Feng, Xie Yuying, Zhang Bin, Zhang Zhijie, Liang Sijia, Chen Fujia, Huang Xiaochao, Wang Hengshan
Abstract excerpt
Dual- or multi-targeted EGFR inhibitors as single drugs can overcome EGFR inhibitor resistance and circumvent many disadvantages of combination therapy. In this work, fifteen 4-anilinoquinazoline derivatives bearing nitrogen mustard or hemi mustard moieties were designed and synthesized as dual EGFR-DNA targeting anticancer agents. Structures of target molecules were confirmed by 1H NMR, 13C NMR and HR-MS, and...
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