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Article

Proteomics and Precise Exercise Phenotypes in Heart Failure With Preserved Ejection Fraction: A Pilot Study.

Journal of the American Heart Association - 7 Nov 2023

Shah Ravi V, Hwang Shih-Jen, Murthy Venkatesh L, Zhao Shilin, Tanriverdi Kahraman, Gajjar Priya, Duarte Kevin, Schoenike Mark, Farrell Robyn, Brooks Liana C, Gopal Deepa M, Ho Jennifer E, Girerd Nicholas, Vasan Ramachandran S, Levy Daniel, Freedman Jane E, Lewis Gregory D, Nayor Matthew

Abstract excerpt

BACKGROUND: While exercise impairments are central to symptoms and diagnosis of heart failure with preserved ejection fraction (HFpEF), prior studies of HFpEF biomarkers have mostly focused on resting phenotypes. We combined precise exercise phenotypes with cardiovascular proteomics to identify protein signatures of HFpEF exercise responses and new potential therapeutic targets. METHODS AND RESULTS: We analyzed...

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Identifiers

PMID: 37889181
DOI: 10.1161/JAHA.122.029980
PMCID: PMC10727424

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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