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Article

Distinct Exercise Response Patterns in Patients With Heart Failure With Preserved Ejection Fraction.

Journal of the American Heart Association - 21 Jul 2026

De Schutter Stephanie, Pugliese Nicola R, Meems Laura M G, Moura-Ferreira Sara, De Biase Nicolò, Del Punta Lavinia, Masi Stefano, Stassen Jan, Herbots Lieven, Claessen Guido, Van de Heyning Caroline M, Verwerft Jan, Gevaert Andreas B

Abstract excerpt

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disease characterized by exercise intolerance. Defining pathophysiologically distinct subgroups allows more personalized therapy, but efforts mainly relied on resting examinations. This study aimed to define HFpEF phenotypes based on exercise limitations using combined cardiopulmonary exercise testing with stress...

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Exercise Test
Exercise Tolerance
Heart Failure
Phenotype

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Ventricular Function, Left

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PMID: 42432452
DOI: 10.1161/JAHA.126.050524
PMCID: PMC13477287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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