Article
Mucosal-Associated Invariant T Cells Are Depleted and Exhibit Altered Chemokine Receptor Expression and Elevated Granulocyte Macrophage-Colony Stimulating Factor Production During End-Stage Renal Disease.
Frontiers in immunology - 1 Jan 2018
Juno Jennifer A, Waruk Jillian L M, Wragg Kathleen M, Mesa Christine, Lopez Carmen, Bueti Joe, Kent Stephen J, Ball T Blake, Kiazyk Sandra A
Abstract excerpt
Background: End-stage renal disease (ESRD) is associated with an increased susceptibility to infectious diseases, including infection with Mycobacterium tuberculosis (Mtb). Mucosal-associated invariant T (MAIT) cells recognize vitamin B metabolites produced by many bacterial species, including Mtb, and may play an important role in providing protective immunity against tuberculosis infection in the lung. To date,...
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