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Article

Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes.

Nature immunology - 1 Jan 2013

Hasan Maroof, Koch James, Rakheja Dinesh, Pattnaik Asit K, Brugarolas James, Dozmorov Igor, Levine Beth, Wakeland Edward K, Lee-Kirsch Min Ae, Yan Nan

Abstract excerpt

The sensing of viral nucleic acids by the innate immune system triggers the production of type I interferons, which activates interferon-stimulated genes (ISGs) and directs a multifaceted antiviral response. ISGs can also be activated through interferon-independent pathways, although the precise mechanisms remain elusive. Here we found that the cytosolic exonuclease Trex1 regulated the activation of a subset of...

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Share to Antigens, Viral
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interferons

Share to Lysosomes

Share to Organelle Biogenesis

Share to RNA, Small Interfering

Share to RNA Virus Infections

Share to RNA Viruses

Source

Open in PubMed Open full text

Identifiers

PMID: 23160154
DOI: 10.1038/ni.2475
PMCID: PMC3522772

Genes

TBK1
TFEB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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