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Article

TreeKernel: interpretable kernel machine tests for interactions between -omics and clinical predictors with applications to metabolomics and COPD phenotypes.

BMC bioinformatics - 25 Oct 2023

Carpenter Charlie M, Gillenwater Lucas, Bowler Russell, Kechris Katerina, Ghosh Debashis

Abstract excerpt

BACKGROUND: In this paper, we are interested in interactions between a high-dimensional -omics dataset and clinical covariates. The goal is to evaluate the relationship between a phenotype of interest and a high-dimensional omics pathway, where the effect of the omics data depends on subjects' clinical covariates (age, sex, smoking status, etc.). For instance, metabolic pathways can vary greatly between sexes...

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Identifiers

PMID: 37880571
DOI: 10.1186/s12859-023-05459-x
PMCID: PMC10601228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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