Article
The lipolysis inhibitor acipimox reverses the cardiac phenotype induced by electronic cigarettes.
Scientific reports - 25 Oct 2023
Espinoza-Derout Jorge, Arambulo Jose Mari Luis, Ramirez-Trillo William, Rivera Juan Carlos, Hasan Kamrul M, Lao Candice J, Jordan Maria C, Shao Xuesi M, Roos Kenneth P, Sinha-Hikim Amiya P, Friedman Theodore C
Abstract excerpt
Electronic cigarettes (e-cigarettes) are a prevalent alternative to conventional nicotine cigarettes among smokers and people who have never smoked. Increased concentrations of serum free fatty acids (FFAs) are crucial in generating lipotoxicity. We studied the effects of acipimox, an antilipolytic drug, on e-cigarette-induced cardiac dysfunction. C57BL/6J wild-type mice on high fat diet were treated with saline,...
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