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Article

Inhibition of Autophagy Signaling via 3-methyladenine Rescued Nicotine-Mediated Cardiac Pathological Effects and Heart Dysfunctions.

International journal of biological sciences - 1 Jan 2020

Zhang Peng, Li Yong, Fu Yingjie, Huang Lei, Liu Bailin, Zhang Lubo, Shao Xuesi M, Xiao Daliao

Abstract excerpt

Rationale: Cigarette smoking is a well-established risk factor for myocardial infarction and sudden cardiac death. The deleterious effects are mainly due to nicotine, but the mechanisms involved and theranostics remain unclear. Thus, we tested the hypothesis that nicotine exposure increases the heart sensitivity to ischemia/reperfusion injury and dysfunction, which can be rescued by autophagy inhibitor. Methods:...

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Identifiers

PMID: 32210724
DOI: 10.7150/ijbs.41275
PMCID: PMC7085229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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