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Differential ferroptosis regulation in red and white gastrocnemius under obesity and its Attenuation by exercise and dietary restriction

3 Jul 2025

Abstract excerpt

Obesity is a global health challenge associated with metabolic dysfunction and chronic diseases. Ferroptosis, an iron-dependent form of regulated cell death characterised by lipid peroxidation and iron accumulation, has been implicated in obesity-related muscle pathology. However, the muscle type-specific regulation of ferroptosis in obesity remains unclear. This study investigates the impact of obesity on...

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PMID: 40610696
DOI: 10.1038/s41598-025-09519-5

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