Article
Global-scale GWAS associates a subset of SNPs with animal-adapted variants in M. tuberculosis complex.
BMC medical genomics - 24 Oct 2023
Brenner Evan P, Sreevatsan Srinand
Abstract excerpt
BACKGROUND: While Mycobacterium tuberculosis complex (MTBC) variants are clonal, variant tuberculosis is a human-adapted pathogen, and variant bovis infects many hosts. Despite nucleotide identity between MTBC variants exceeding 99.95%, it remains unclear what drives these differences. Markers of adaptation into variants were sought by bacterial genome-wide association study of single nucleotide polymorphisms...
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