Article

Three Patients With Disseminated Mycobacterial Infections Due to Severe Defects in Interferon Gamma Receptor Signaling: A Challenging Diagnosis

2021-07-09

Abstract excerpt

<title>Abstract</title> <p>IFN–gamma receptor (IFNGR) signaling via STAT1 is crucial in the defense against intracellular pathogens. Defects in this pathway enhance the susceptibility to infection by otherwise weak pathogenic mycobacteria, resulting in a primary immunodeficiency called mendelian susceptibility to mycobacterial disease (MSMD). Here we describe three patients with MSMD caused by variants in the IFN...

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Literature Corpus work: 60e1805f-150a-5354-8545-db1d072f4761
DOI: 10.21203/rs.3.rs-682108/v1

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