Article
Life-course adiposity and severe liver disease: a Mendelian randomization analysis.
Obesity (Silver Spring, Md.) - 1 Dec 2023
Wang Xinyu, Wu Zhiyu, Lv Jun, Yu Canqing, Sun Dianjianyi, Pei Pei, Yang Ling, Millwood Iona Y, Walters Robin, Chen Yiping, Du Huaidong, Yuan Mingqiang, Schmidt Dan, Barnard Maxim, Chen Junshi, Chen Zhengming, Li Liming, Pang Yuanjie
Abstract excerpt
OBJECTIVE: There is little evidence on the genetic associations between life-course adiposity (including birth weight, childhood BMI, and adulthood BMI) and severe liver disease (SLD; including cirrhosis and liver cancer). The current study aimed to examine and contrast these associations. METHODS: Genetic variants were obtained from genome-wide association studies. Two-sample Mendelian randomization (MR)...
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