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Article

Virtual Screening and In Vitro Evaluation of PD-1 Dimer Stabilizers for Uncoupling PD-1/PD-L1 Interaction from Natural Products.

Molecules (Basel, Switzerland) - 13 Nov 2020

Lung Jrhau, Hung Ming-Szu, Lin Yu-Ching, Hung Chien-Hui, Chen Chih-Cheng, Lee Kuan-Der, Tsai Ying Huang

Abstract excerpt

Genetic mutations accumulated overtime could generate many growth and survival advantages for cancer cells, but these mutations also mark cancer cells as targets to be eliminated by the immune system. To evade immune surveillance, cancer cells adopted different intrinsic molecules to suppress immune response. PD-L1 is frequently overexpressed in many cancer cells, and its engagement with PD-1 on T cells...

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Identifiers

PMID: 33202823
DOI: 10.3390/molecules25225293
PMCID: PMC7696397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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