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UGT1A polymorphism rs4148324 associated with topiramate plasma concentration to dose ratio in children with epilepsy.

Seizure - 1 Mar 2024

Wei Shifeng, Li Xingmeng, Wu Han, Zhang Qiang, Wu Yun, Zhao Zhigang, Mei Shenghui, Feng Weixing

Abstract excerpt

PURPOSE: The objective of this study is to evaluate the association between genetic polymorphisms and the concentration to dose ratio of topiramate in children with epilepsy. METHODS: A cohort of 163 pediatric patients with epilepsy receiving topiramate therapy were enrolled. The ultra-performance liquid chromatography-tandem mass spectrometry method was employed to measure the trough plasma concentration of...

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PMID: 37858371
DOI: 10.1016/j.seizure.2023.10.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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