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Article

The protective effect of growth hormone on Cu/Zn superoxide dismutase-mutant motor neurons.

BMC neuroscience - 6 Feb 2015

Chung Jin-Young, Kim Hyun-Jung, Kim Manho

Abstract excerpt

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is characterized by selective degeneration of motor neurons. The gene encoding Cu/Zn superoxide dismutase (SOD1) is responsible for 20% of familial ALS cases. Growth hormone (GH) concentrations are low in the cerebrospinal fluid of patients with ALS; however, its association with motoneuronal death is not known. We tested the neuroprotective effects of GH on human...

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Source

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Identifiers

PMID: 25655275
DOI: 10.1186/s12868-015-0140-z
PMCID: PMC4326297

Genes

GFAP
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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