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Article

Alzheimer's polygenic risk scores are associated with cognitive phenotypes in Down syndrome.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2024

Gorijala Priyanka, Aslam M Muaaz, Dang Lam-Ha T, Xicota L, Fernandez Maria V, Sung Yun Ju, Fan Kang-Hsien, Feingold Eleanor, Surace Ezequiel I, Chhatwal Jasmeer P, Hom Christy L, Hartley Sigan L, Hassenstab Jason, Perrin Richard J, Mapstone Mark, Zaman Shahid H, Ances Beau M, Kamboh M Ilyas, Lee Joseph H, Cruchaga Carlos

Abstract excerpt

INTRODUCTION: This study aimed to investigate the influence of the overall Alzheimer's disease (AD) genetic architecture on Down syndrome (DS) status, cognitive measures, and cerebrospinal fluid (CSF) biomarkers. METHODS: AD polygenic risk scores (PRS) were tested for association with DS-related traits. RESULTS: The AD risk PRS was associated with disease status in several cohorts of sporadic late- and...

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Identifiers

PMID: 37855447
DOI: 10.1002/alz.13506
PMCID: PMC10916941

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