Article
Genome-wide association analyses identify candidate loci for amyloid imaging and plasma biomarkers in adults with Down syndrome.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2025
Aslam M Muaaz, Dang Lam-Ha T, Shi Ruyu, Fan Kang-Hsien, Cheema Asma Naseer, Xicota Laura, Minhas Danveet, Luo Weiquan, Zafari Narges, Acharya Vibha, Feingold Eleanor, Krinsky-McHale Sharon, Laymon Charles M, Cohen Ann, Handen Benjamin L, Christian Bradley T, Head Elizabeth, Mapstone Mark E, Lee Joseph H, Cruchaga Carlos, Kamboh M Ilyas
Abstract excerpt
BACKGROUND: People with Down syndrome (DS) overproduce amyloid-beta (Aβ) due to triplication of the amyloid precursor protein (APP) gene on chromosome 21, and consequently accumulate brain amyloid load at younger ages. We conducted genome-wide association (GWA) analyses on amyloid imaging and plasma biomarkers to discern the genetic architecture of amyloid burden in DS. METHODS: GWA analyses were performed on...
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