Article
CYP1A2*F Polymorphism Contributes at Least Partially to the Variability of Plasma Levels of Dehydroaripiprazole, an Active Metabolite of Aripiprazole, in Schizophrenic Patients.
Drug metabolism and bioanalysis letters - 1 Jan 2024
Suzuki Takeshi, Nagai Goyo, Mihara Kazuo, Tomori Yoko, Kagawa Shoko, Nakamura Akifumi, Nemoto Kenji, Kondo Tsuyoshi
Abstract excerpt
AIM: The relationship between CYP1A2 polymorphisms and the steady-state plasma levels of aripiprazole and its active metabolite, dehydroaripiprazole, were investigated in Japanese schizophrenic patients. BACKGROUND: It has been implied that cytochrome P450 (CYP) 1A2 may play a role in the metabo-lism of aripiprazole. Genetic variations in the CYP1A2 gene have been reported. OBJECTIVE: The authors investigated the...
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