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Article

HLA haplotypes and differential regional mortality caused by COVID-19 in Brazil: an ecological study based on a large bone marrow donor bank dataset.

Anais da Academia Brasileira de Ciencias - 1 Jan 2023

Boquett Juliano André, Vianna Fernanda S L, Fagundes Nelson J R, Schroeder Lucas, Barbian Marcia, Zagonel-Oliveira Marcelo, Andreis Tiago F, Pôrto Luis Cristóvão M S, Chies José Artur B, Schuler-Faccini Lavinia, Ashton-Prolla Patricia, Rosset Clévia

Abstract excerpt

The coronavirus disease 2019 (COVID-19) mortality rates varied among the states of Brazil during the course of the pandemics. The human leukocyte antigen (HLA) is a critical component of the antigen presentation pathway. Individuals with different HLA genotypes may trigger different immune responses against pathogens, which could culminate in different COVID-19 responses. HLA genotypes are variable, especially in...

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PMID: 37851747
DOI: 10.1590/0001-3765202320220801

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