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HLA and AB0 Polymorphisms May Influence SARS-CoV-2 Infection and COVID-19 Severity.

Transplantation - 1 Jan 2021

Amoroso Antonio, Magistroni Paola, Vespasiano Francesca, Bella Antonino, Bellino Stefania, Puoti Francesca, Alizzi Silvia, Vaisitti Tiziana, Boros Stefano, Grossi Paolo Antonio, Trapani Silvia, Lombardini Letizia, Pezzotti Patrizio, Deaglio Silvia, Brusaferro Silvio, Cardillo Massimo

Abstract excerpt

BACKGROUND: SARS-CoV-2 infection is heterogeneous in clinical presentation and disease evolution. To investigate whether immune response to the virus can be influenced by genetic factors, we compared HLA and AB0 frequencies in organ transplant recipients and waitlisted patients according to presence or absence of SARS-CoV-2 infection. METHODS: A retrospective analysis was performed on an Italian cohort composed...

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PMID: 33141807
DOI: 10.1097/TP.0000000000003507

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