Article
Identification of associations between genotypes and longitudinal phenotypes via temporally-constrained group sparse canonical correlation analysis.
Bioinformatics (Oxford, England) - 15 Jul 2017
Hao Xiaoke, Li Chanxiu, Yan Jingwen, Yao Xiaohui, Risacher Shannon L, Saykin Andrew J, Shen Li, Zhang Daoqiang
Abstract excerpt
MOTIVATION: Neuroimaging genetics identifies the relationships between genetic variants (i.e., the single nucleotide polymorphisms) and brain imaging data to reveal the associations from genotypes to phenotypes. So far, most existing machine-learning approaches are widely used to detect the effective associations between genetic variants and brain imaging data at one time-point. However, those associations are...
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