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Article

Detecting genetic associations with brain imaging phenotypes in Alzheimer's disease via a novel structured SCCA approach.

Medical image analysis - 1 Apr 2020

Du Lei, Liu Kefei, Yao Xiaohui, Risacher Shannon L, Han Junwei, Saykin Andrew J, Guo Lei, Shen Li

Abstract excerpt

Brain imaging genetics becomes an important research topic since it can reveal complex associations between genetic factors and the structures or functions of the human brain. Sparse canonical correlation analysis (SCCA) is a popular bi-multivariate association identification method. To mine the complex genetic basis of brain imaging phenotypes, there arise many SCCA methods with a variety of norms for...

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PMID: 32062154
DOI: 10.1016/j.media.2020.101656
PMCID: PMC7099577

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