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Article

Brain-Wide Genome-Wide Association Study for Alzheimer's Disease via Joint Projection Learning and Sparse Regression Model.

IEEE transactions on bio-medical engineering - 1 Jan 2019

Zhou Tao, Thung Kim-Han, Liu Mingxia, Shen Dinggang

Abstract excerpt

Brain-wide and genome-wide association (BW-GWA) study is presented in this paper to identify the associations between the brain imaging phenotypes (i.e., regional volumetric measures) and the genetic variants [i.e., single nucleotide polymorphism (SNP)] in Alzheimer's disease (AD). The main challenges of this study include the data heterogeneity, complex phenotype-genotype associations, high-dimensional data...

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Identifiers

PMID: 29993426
DOI: 10.1109/TBME.2018.2824725
PMCID: PMC6342004

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