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Article

TERRA R-loops connect and protect sister telomeres in mitosis

1 Oct 2023

Abstract excerpt

Resolution of cohesion between sister telomeres in human cells depends on TRF1-mediated recruitment of the polyADP-ribosyltransferase tankyrase to telomeres. In human aged cells, due to insufficient recruitment of TRF1/tankyrase to shortened telomeres, sisters remain cohered in mitosis. This persistent cohesion plays a protective role, but the mechanism by which sisters remain cohered is not well understood. Here...

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Identifiers

PMID: 37843976
DOI: 10.1016/j.celrep.2023.113235

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