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Article

Persistent telomere cohesion protects aged cells from premature senescence.

Nature communications - 3 Jul 2020

Azarm Kameron, Bhardwaj Amit, Kim Eugenie, Smith Susan

Abstract excerpt

Human telomeres are bound by the telomere repeat binding proteins TRF1 and TRF2. Telomere shortening in human cells leads to a DNA damage response that signals replicative senescence. While insufficient loading of TRF2 at shortened telomeres contributes to the DNA damage response in senescence, the contribution of TRF1 to senescence induction has not been determined. Here we show that counter to TRF2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32620872
DOI: 10.1038/s41467-020-17133-4
PMCID: PMC7335080

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