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Article

Using structural equation modelling to jointly estimate maternal and fetal effects on birthweight in the UK Biobank.

International journal of epidemiology - 1 Aug 2018

Warrington Nicole M, Freathy Rachel M, Neale Michael C, Evans David M

Abstract excerpt

Background: To date, 60 genetic variants have been robustly associated with birthweight. It is unclear whether these associations represent the effect of an individual's own genotype on their birthweight, their mother's genotype, or both. Methods: We demonstrate how structural equation modelling (SEM) can be used to estimate both maternal and fetal effects when phenotype information is present for individuals in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29447406
DOI: 10.1093/ije/dyy015
PMCID: PMC6124616

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