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Assessment of ERBB2 and EGFR gene amplification and protein expression in gastric carcinoma by immunohistochemistry and fluorescence in situ hybridization

1 Jan 2011

Abstract excerpt

BACKGROUND: The goal of this study was to investigate ERBB2(HER2) and EGFR gene amplification and protein expression in gastric cancer. Fluorescence in situ hybridization (FISH) and immunohistochemistry were used to analyze ERBB2 and EGFR gene amplification and protein expression in 69 cases of gastric cancer. RESULTS: FISH analysis revealed that 20.3% of the cases exhibited ERBB2 gene amplification. Increases in...

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PMID: 21689422
DOI: 10.1186/1755-8166-4-14

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