Early molecular events of autosomal-dominant Alzheimer's disease in marmosets with PSEN1 mutations.

doi:10.1002/alz.13806

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Article

Early molecular events of autosomal-dominant Alzheimer's disease in marmosets with PSEN1 mutations.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2024

Homanics Gregg E, Park Jung Eun, Bailey Lauren, Schaeffer David J, Schaeffer Lauren, He Jie, Li Shuoran, Zhang Tingting, Haber Annat, Spruce Catrina, Greenwood Anna, Murai Takeshi, Schultz Laura, Mongeau Lauren, Ha Seung-Kwon, Oluoch Julia, Stein Brianne, Choi Sang Ho, Huhe Hasi, Thathiah Amantha, Strick Peter L, Carter Gregory W, Silva Afonso C, Sukoff Rizzo Stacey J

Abstract excerpt

INTRODUCTION: Fundamental questions remain about the key mechanisms that initiate Alzheimer's disease (AD) and the factors that promote its progression. Here we report the successful generation of the first genetically engineered marmosets that carry knock-in (KI) point mutations in the presenilin 1 (PSEN1) gene that can be studied from birth throughout lifespan. METHODS: CRISPR/Cas9 was used to generate...

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PMID: 38574388
DOI: 10.1002/alz.13806
PMCID: PMC11095452

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