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Article

Bactabolize is a tool for high-throughput generation of bacterial strain-specific metabolic models.

eLife - 10 Oct 2023

Vezina Ben, Watts Stephen C, Hawkey Jane, Cooper Helena B, Judd Louise M, Jenney Adam W J, Monk Jonathan M, Holt Kathryn E, Wyres Kelly L

Abstract excerpt

Metabolic capacity can vary substantially within a bacterial species, leading to ecological niche separation, as well as differences in virulence and antimicrobial susceptibility. Genome-scale metabolic models are useful tools for studying the metabolic potential of individuals, and with the rapid expansion of genomic sequencing there is a wealth of data that can be leveraged for comparative analysis. However,...

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Identifiers

PMID: 37815531
DOI: 10.7554/eLife.87406
PMCID: PMC10564454

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