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Genetic features of TP53 mutation and its downstream FOXA1 in prostate cancer.

Bioscience trends - 20 Jul 2022

Xu Xiaofei, Xie Limei, Meng Liwei, Geng Shangzhen, Liu Jin, Cao Xiangting, Dong Zhaogang, Xing Zhaoquan

Abstract excerpt

Metastasis is the most lethal form of prostate cancer, and finding new therapeutic targets remains a major clinical challenge. TP53 mutation has been identified to be involved in tumor progression and metastasis. Nevertheless, direct evidence of the role of TP53 mutation in prostate cancer metastasis and its underlying mechanism remain obscure. Herein, TP53 was found to be the most mutated gene in prostate...

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PMID: 35768267
DOI: 10.5582/bst.2022.01235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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