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Article

A three-dimensional model of human lung development and disease from pluripotent stem cells.

Nature cell biology - 1 May 2017

Chen Ya-Wen, Huang Sarah Xuelian, de Carvalho Ana Luisa Rodrigues Toste, Ho Siu-Hong, Islam Mohammad Naimul, Volpi Stefano, Notarangelo Luigi D, Ciancanelli Michael, Casanova Jean-Laurent, Bhattacharya Jahar, Liang Alice F, Palermo Laura M, Porotto Matteo, Moscona Anne, Snoeck Hans-Willem

Abstract excerpt

Recapitulation of lung development from human pluripotent stem cells (hPSCs) in three dimensions (3D) would allow deeper insight into human development, as well as the development of innovative strategies for disease modelling, drug discovery and regenerative medicine. We report here the generation from hPSCs of lung bud organoids (LBOs) that contain mesoderm and pulmonary endoderm and develop into branching...

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Identifiers

PMID: 28436965
DOI: 10.1038/ncb3510
PMCID: PMC5777163

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HPS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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