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Article

Geographical distribution of cystic fibrosis carriers as population genetic determinant of COVID-19 spread and fatality in 37 countries.

The Journal of infection - 1 Sept 2022

Gabbi Chiara, Renieri Alessandra, Strandvik Birgitta

Abstract excerpt

COVID-19 has shown a relevant heterogeneity in spread and fatality among countries together with a significant variability in its clinical presentation, indicating that host genetic factors may influence COVID-19 pathogenicity. Indeed, subjects carrying single pathogenic variants of the Cystic Fibrosis (CF) Transmembrane Conductance Regulator (CFTR) gene - i.e. CF carriers - are more susceptible to respiratory...

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Identifiers

PMID: 35700866
DOI: 10.1016/j.jinf.2022.06.006
PMCID: PMC9188282

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