Heterozygosity for the F508del mutation in the cystic fibrosis transmembrane conductance regulator anion channel attenuates influenza severity.

doi:10.1093/infdis/jit251

Article

Heterozygosity for the F508del mutation in the cystic fibrosis transmembrane conductance regulator anion channel attenuates influenza severity.

The Journal of infectious diseases - 1 Sept 2013

Aeffner Famke, Abdulrahman Basant, Hickman-Davis Judy M, Janssen Paul M, Amer Amal, Bedwell David M, Sorscher Eric J, Davis Ian C

Abstract excerpt

BACKGROUND: Seasonal and pandemic influenza are significant public health concerns. Influenza stimulates respiratory epithelial Cl(-) secretion via the cystic fibrosis transmembrane conductance regulator (CFTR). The purpose of this study was to determine the contribution of this effect to influen...

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