Heterozygosity for the F508del mutation in the cystic fibrosis transmembrane conductance regulator anion channel attenuates influenza severity.

doi:10.1093/infdis/jit251

Article

Heterozygosity for the F508del mutation in the cystic fibrosis transmembrane conductance regulator anion channel attenuates influenza severity.

The Journal of infectious diseases - 1 Sept 2013

Aeffner Famke, Abdulrahman Basant, Hickman-Davis Judy M, Janssen Paul M, Amer Amal, Bedwell David M, Sorscher Eric J, Davis Ian C

Abstract excerpt

BACKGROUND: Seasonal and pandemic influenza are significant public health concerns. Influenza stimulates respiratory epithelial Cl(-) secretion via the cystic fibrosis transmembrane conductance regulator (CFTR). The purpose of this study was to determine the contribution of this effect to influenza pathogenesis in mice with reduced CFTR activity. METHODS: C57BL/6-congenic mice heterozygous for the F508del CFTR...

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