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“Idiopathic” minimal change nephrotic syndrome: a podocyte mystery nears the end

5 Oct 2023

Abstract excerpt

The discovery of zinc fingers and homeoboxes (ZHX) transcriptional factors and the upregulation of hyposialylated angiopoietin-like 4 (ANGPTL4) in podocytes have been crucial in explaining the cardinal manifestations of human minimal change nephrotic syndrome (MCNS). Recently, uncovered genomic defects upstream of ZHX2 induce a ZHX2 hypomorph state that makes podocytes inherently susceptible to mild cytokine...

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PMID: 37795536
DOI: 10.1152/ajprenal.00219.2023

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