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Article

Molecular Mechanisms of Proteinuria in Minimal Change Disease

23 Dec 2021

Abstract excerpt

Minimal change disease (MCD) is the most common type of idiopathic nephrotic syndrome in childhood and represents about 15% cases in adults. It is characterized by massive proteinuria, edema, hypoalbuminemia, and podocyte foot process effacement on electron microscopy. Clinical and experimental studies have shown an association between MCD and immune dysregulation. Given the lack of inflammatory changes or...

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PMID: 35004732
DOI: 10.3389/fmed.2021.761600

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