Article

Cell biology and genetics of minimal change disease

2016-03-30

Abstract excerpt

Minimal change disease (MCD) is an important cause of nephrotic syndrome and is characterized by massive proteinuria and hypoalbuminemia, resulting in edema and hypercholesterolemia. The podocyte plays a key role in filtration and its disruption results in a dramatic loss of function leading to proteinuria. Immunologic disturbance has been suggested in the pathogenesis of MCD. Because of its clinical features, suc...

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Literature Corpus work: 53a22fdf-1a09-563c-91b6-d8a725f45103
DOI: 10.12688/f1000research.7300.1

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