Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

European Colonial Echoes in Cancer Risk: Lessons from the TP53 p.R337H Founder Variant in Brazil.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 3 Feb 2026

Carvajal-Carmona Luis G

Abstract excerpt

Latin America's population is among the most genetically diverse in the world, shaped by centuries of European colonization, Indigenous American displacement, and forced African slave migration. This complex ancestry, combined with persistent social inequalities, influences cancer risk through both genetic and environmental factors. For example, Indigenous ancestry has been linked to a lower risk of breast...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brazil
Share to Founder Effect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to TP53 gene

Share to Genetic Predisposition to Disease

Share to Mutation

Share to Neoplasms

Share to Risk Factors

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 41630583
DOI: 10.1158/1055-9965.EPI-25-1843

Genes

TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

European Colonial Echoes in Cancer Risk: Lessons from the TP53 p.R337H Founder Variant in Brazil.PMID 41630583Read ↗

Reconstructing the Origin and Demographic Expansion of the TP53 p.R337H Founder Variant in Brazil.Semantic proximity Read ↗

Multiple TP53 p.R337H haplotypes and implications for tumor susceptibilitySemantic proximity Read ↗

TP53 p.R337H Germline Variant among Women at Risk of Hereditary Breast Cancer in a Public Health System of Midwest Brazil.Semantic proximity Read ↗

Founder and Recurrent Mutations in BRCA1 and BRCA2 Genes in Latin American Countries: State of the Art and Literature Review.Semantic proximity Read ↗

What 20 years of research has taught us about the TP53 p.R337H mutation.Semantic proximity Read ↗

TP53 mutations as biomarkers for cancer epidemiology in Latin America: current knowledge and perspectives.Semantic proximity Read ↗

State of Art of Cancer Pharmacogenomics in Latin American Populations.Semantic proximity Read ↗

Academic and Institutional Contributions to Cancer Genetics in Brazil and Latin America: A Contextual Analysis.Semantic proximity Read ↗

Academic and Institutional Contributions to Cancer Genetics in Brazil and Latin America: A Contextual Analysis.Semantic proximity Read ↗

Germline mutations in BRCA1, BRCA2, CHEK2 and TP53 in patients at high-risk for HBOC: characterizing a Northeast Brazilian PopulationSemantic proximity Read ↗

Detailed haplotype analysis at the TP53 locus in p.R337H mutation carriers in the population of Southern Brazil: evidence for a founder effect.Semantic proximity Read ↗

Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.