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Article

Identification of additional mechanistically important residues in the multidrug transporter styMdtM of Salmonella Typhi.

Journal of biomolecular structure & dynamics - 1 Jan 2024

Shaheen Aqsa, Tariq Anam, Ismat Fouzia, Naveed Hammad, De Zorzi Rita, Iqbal Mazhar, Storici Paola, Mirza Osman, Walz Thomas, Rahman Moazur

Abstract excerpt

Multidrug efflux is a well-established mechanism of drug resistance in bacterial pathogens like Salmonella Typhi. styMdtM (locus name; STY4874) is a multidrug efflux transporter of the major facilitator superfamily expressed in S. Typhi. Functional assays identified several residues important for its transport activity. Here, we used an AlphaFold model to identify additional residues for analysis by mutagenesis....

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Share to Bacterial Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37787617
DOI: 10.1080/07391102.2023.2263882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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