Article
HIF-1α and periodontitis: Novel insights linking host-environment interplay to periodontal phenotypes.
Progress in biophysics and molecular biology - 1 Nov 2023
Shan Chao, Xia YuNing, Wu Zeyu, Zhao Jin
Abstract excerpt
Periodontitis, the sixth most prevalent epidemic disease globally, profoundly impacts oral aesthetics and masticatory functionality. Hypoxia-inducible factor-1α (HIF-1α), an oxygen-dependent transcriptional activator, has emerged as a pivotal regulator in periodontal tissue and alveolar bone metabolism, exerts critical functions in angiogenesis, erythropoiesis, energy metabolism, and cell fate determination....
Topics
- Humans
- Periodontitis
- Hypoxia-Inducible Factor 1, alpha Subunit
- Animals
- Phenotype
- Periodontium