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Impact of Resolvin D1 on the inflammatory phenotype of periodontal ligament cell response to hypoxia.

Journal of periodontal research - 1 Oct 2022

Cai Jiazheng, Liu Jing, Yan Jing, Lu Xuexia, Wang Xiaoli, Li Si, Mustafa Kamal, Wang Huihui, Xue Ying, Mustafa Manal, Kantarci Alpdogan, Xing Zhe

Abstract excerpt

OBJECTIVE: Periodontal ligament cells (PDLCs) are critical for wound healing and regenerative capacity of periodontal diseases. Within an inflammatory periodontal pocket, a hypoxic environment can aggravate periodontal inflammation, where PDLCs response to the inflammation would change. Resolvin D1 (RvD1) is an endogenous lipid mediator, which can impact intracellular inflammatory pathways of periodontal/oral...

Topics

Cells, Cultured
Docosahexaenoic Acids
Humans
Hypoxia
Inflammation
Osteogenesis
Periodontal Ligament
Phenotype
Proto-Oncogene Proteins c-akt
p38 Mitogen-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35944267
DOI: 10.1111/jre.13044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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