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Article

Lipopolysaccharide and hypoxia-induced HIF-1 activation in human gingival fibroblasts.

Journal of periodontology - 1 Jun 2012

Li Jing-Ping, Li François Y L, Xu Aimin, Cheng Bin, Tsao Sai Wah, Fung Man-Lung, Leung W Keung

Abstract excerpt

BACKGROUND: We previously reported that chronic periodontal inflammation causes the accumulation of the transcriptional activator hypoxia-inducible factor-1α (HIF-1α) in human gingival fibroblasts (HGFs) in vivo. Here, evidence is provided that bacterial lipopolysaccharides (LPS) and cellular hypoxia, both associated with periodontitis, can individually, or in combination, lead to the accumulation and activation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22087807
DOI: 10.1902/jop.2011.110458

Genes

TLR4
HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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