Article
In-host adaptation and acquired triazole resistance in Aspergillus fumigatus: a dilemma for clinical management.
The Lancet. Infectious diseases - 1 Nov 2016
Verweij Paul E, Zhang Jianhua, Debets Alfons J M, Meis Jacques F, van de Veerdonk Frank L, Schoustra Sijmen E, Zwaan Bas J, Melchers Willem J G
Abstract excerpt
Aspergillus fumigatus causes a range of diseases in human beings, some of which are characterised by fungal persistence. A fumigatus can persist by adapting to the human lung environment through physiological and genomic changes. The physiological changes are based on the large biochemical versatility of the fungus, and the genomic changes are based on the capacity of the fungus to generate genetic diversity by...
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