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Article

Genetic correction of TRMU allele restored the mitochondrial dysfunction-induced deficiencies in iPSCs-derived hair cells of hearing-impaired patients.

Human molecular genetics - 10 Sept 2022

Chen Chao, Guan Min-Xin

Abstract excerpt

Sensorineural hearing loss often results from damaged or deficient inner ear hair cells. Mitochondrial 12S rRNA 1555A>G mutation has been associated with hearing loss in many families. The m.1555A>G mutation is a primary factor underlying the development of hearing loss and TRMU allele (c.28G>T, p.Ala10Sser) encoding tRNA thiouridylase interact with m.1555A>G mutation to cause hearing loss. However, the tissue...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35467742
DOI: 10.1093/hmg/ddac096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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