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Article

Modeling policy interventions for slowing the spread of artemisinin-resistant pfkelch R561H mutations in Rwanda.

Nature medicine - 1 Nov 2023

Zupko Robert J, Nguyen Tran Dang, Ngabonziza J Claude S, Kabera Michee, Li Haojun, Tran Thu Nguyen-Anh, Tran Kien Trung, Uwimana Aline, Boni Maciej F

Abstract excerpt

Artemisinin combination therapies (ACTs) are highly effective at treating uncomplicated Plasmodium falciparum malaria, but the emergence of the new pfkelch13 R561H mutation in Rwanda, associated with delayed parasite clearance, suggests that interventions are needed to slow its spread. Using a Rwanda-specific spatial calibration of an individual-based malaria model, we evaluate 26 strategies aimed at minimizing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37735560
DOI: 10.1038/s41591-023-02551-w
PMCID: PMC10667088

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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