Expression of the Hippo transducer TAZ in association with WNT pathway mutations impacts survival outcomes in advanced gastric cancer patients treated with first-line chemotherapy.

doi:10.1186/s12967-018-1385-y

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Article

Expression of the Hippo transducer TAZ in association with WNT pathway mutations impacts survival outcomes in advanced gastric cancer patients treated with first-line chemotherapy.

Journal of translational medicine - 5 Feb 2018

Melucci Elisa, Casini Beatrice, Ronchetti Livia, Pizzuti Laura, Sperati Francesca, Pallocca Matteo, De Nicola Francesca, Goeman Frauke, Gallo Enzo, Amoreo Carla Azzurra, Sergi Domenico, Terrenato Irene, Vici Patrizia, Di Lauro Luigi, Diodoro Maria Grazia, Pescarmona Edoardo, Barba Maddalena, Mazzotta Marco, Mottolese Marcella, Fanciulli Maurizio, Ciliberto Gennaro, De Maria Ruggero, Buglioni Simonetta, Maugeri-Saccà Marcello

Abstract excerpt

BACKGROUND: An extensive crosstalk co-regulates the Hippo and Wnt pathway. Preclinical studies revealed that the Hippo transducers YAP/TAZ mediate a number of oncogenic functions in gastric cancer (GC). Moreover, comprehensive characterization of GC demonstrated that the Wnt pathway is targeted by oncogenic mutations. On this ground, we hypothesized that YAP/TAZ- and Wnt-related biomarkers may predict clinical...

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PMID: 29402328
DOI: 10.1186/s12967-018-1385-y
PMCID: PMC5800016

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APC
CTNNB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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