Article
FLT3 Inhibitors in Acute Myeloid Leukemia: Challenges and Recent Developments in Overcoming Resistance.
Journal of medicinal chemistry - 25 Mar 2021
Wang Zhijie, Cai Jiongheng, Cheng Jie, Yang Wenqianzi, Zhu Yifan, Li Hongmei, Lu Tao, Chen Yadong, Lu Shuai
Abstract excerpt
Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene are often present in newly diagnosed acute myeloid leukemia (AML) patients with an incidence rate of approximately 30%. Recently, many FLT3 inhibitors have been developed and exhibit positive preclinical and clinical effects against AML. How...
Topics
- Animals
- Drug Discovery
- Drug Resistance, Neoplasm
- Humans
- Leukemia, Myeloid, Acute
- Models, Molecular
- Mutation
- Protein Kinase Inhibitors
- Small Molecule Libraries
- fms-Like Tyrosine Kinase 3